Structure Enhancement Relationship of Chemical Penetration Enhancers in Drug Transport across the Stratum Corneum
نویسندگان
چکیده
منابع مشابه
Structure Enhancement Relationship of Chemical Penetration Enhancers in Drug Transport across the Stratum Corneum
The stratum corneum is a major barrier of drug penetration across the skin in transdermal delivery. For effective transdermal drug delivery, skin penetration enhancers are used to overcome this barrier. In the past decades, a number of research studies were conducted to understand the mechanisms of skin penetration enhancers and to develop a structure enhancement relationship. Such understandin...
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Transdermal drug delivery (TDD) is a non-invasive, topical administration method for therapeutic agents. Transdermal delivery also has advantages including providing release for long periods of time, improving patient compliance, and generally being inexpensive. Despite these advantages, the use of TDD has been limited by innate barrier functions of the skin. Only small (<500 Da), lipophilic mo...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2012
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics4010071